The discovery of its role in selective autophagy and the description of BAG3-mediated selective macroautophagy as an adaptive mechanism to maintain cellular homeostasis, under stress as well as during aging, make BAG3 a highly interesting target for future pharmacological interventions.īAG1–BAG3 switch Bcl-2 Hsc/Hsp70 macroautophagy proteasome protein quality control.Ĭopyright © 2016 Elsevier Ltd. Various BAG3 functions are implicated in disorders including cancer, myopathies, and neurodegeneration. Written by Julian Fellowes, based on the novel by Laura Moriarty. Discover who these women are, and who they eventually become. theshimmyshow episode 21 'black m fucker' ft Leilani Lei TRAILER. Norma Carlisle (Elizabeth McGovern) accompanies future star Louise Brooks (Haley Lu Richardson) to New York. BAG3 has a modular protein domain composition offering the possibility for manifold interactions with other proteins. theshimmyshow episode 22 'you need a the ' ft Leilani Lei TRAILER. In addition to their antiapoptotic activity, all human BAG proteins have distinct functions in health and disease, and BAG3 in particular is the focus of many investigations. Via this domain, BAG proteins bind to the heat shock protein 70 (Hsp70), thereby acting as a co-chaperone regulating the activity of Hsp70. The previously untold, true story of a lone teacher chaperoning a peaceful school dance in a 1970s Montreal church basement. I always thought this episode was cute EDIT: There's a high possibility this will be done digitally I will possibly be working on this next weekend.
Human BAG (Bcl-2-associated athanogene) proteins form a family of antiapoptotic proteins that currently consists of six members (BAG1-6) all sharing the BAG protein domain from which the name arises. By peblezQ Published: 2 Favourites 3 Comments 1.2K Views Just a rough storyboard-like sketch comic that is a human version of the ending from the episode 'The Chaperone'.